Yes. A good proportion of the summer traffic on the Alaska Highway is RVs. Drive carefully on the gravel sections, get fuel and supplies where and when available, because you never really know how long it will take to get to the next place that can take care of you. You need to be more self-contained, more self-sufficient that when RV touring in more densely settled parts of the U.S.
My uncle made the round trip by car twice in the 1950s and 1960s, when the roads were not as good as they are today. First time tent camping out of a big car (I think it was a Lincoln), second time he borrowed our travel trailer and hauled it behind a 1958 Mercury Turnpike Cruiser. We did scrap the TT shortly after it came back, because he hauled it from Detroit to Fairbanks to Mexico City and back, pretty well worn out when he was done.
National Parks in Alaska are not necessarily highway accessible, but you'll be driving through more wilderness than you can see in most of the National Parks in the lower 48.