The tourism-related businesses have been hit pretty hard up here from all the impacts of the virus, whether border crossing, State mandates, City mandates, Village mandates, lack of revenue etc.
Many places had pre-emptively shut down for the year...including a couple of very well-known flight outfits...but others saw a bit of an uptick for August, although probably not enough and not much of an uptick for businesses dependent on road traffic.
Anecdotally, we've gone to Seward a few times and: a) had no problem getting a hotel room in July and August...usually very difficult; and b) would have had no problem getting a fishing charter except 4 people would have been paying for 6 slots....so we took our own boat instead. Similarly anecdotally, Brand X and Y were shutdown for flightseeing around McKinley and River Charter Co. ABC was shutdown because they couldn't justify paying the seasonal help with the reduced customer demand.
I guesstimate that the critical path to RV travel in Alaska in 2021 will depend on the border status: businesses being open is probably a bit of "who knows" but again my guesstimate would be that some (as opposed to "Most") of the tourism-based venues and activities will be available.
Regarding the AMHS, there is the cross-gulf ferry option that gets one from Southeast into "Southcentral" (Valdez, whittier, etc) but it's a real likelihood that that will be on a very reduced schedule in 2021.