Just a pre-planning note, many of the usual attractions that visitors (of all types) like to visit are tied to one degree or the other to the cruise ship crowd (even in SC Alaska, such as Los Anchorage and Talkeetna). Whether or not the cruise ships return at something near usual levels will have an effect on whether some of the tours / activities / services are also back to their pre-restriction levels.
Even assuming the border stays "open", it would be well to check with one's intended destination / attraction to make sure it's open in 2022....even if that just means a decision to turn right to Fairbanks or left to Glennallen / Anchorage