Best route from Lafayette In to AAsheville NC?

In and out of Asheville from Knoxville on I-40 doesn't really involve mountain driving. There are a few very short somewhat steep-ish grades, but it's mostly curves and a few tunnels. The road mostly follows the Pigeon River Gorge thru the mountains, and it's a fairly gentle climb eastbound. Just get in the right lane and follow the trucks. They're limited to the right lane and 50 mph; it's a good speed to keep thru there.

Jim, "The best way to forget all your troubles is to wear tight shoes."