Several people have recommended US2. If you take US2 you can see the Great Lakes, Mackinaw City, Soo Locks in Sault St Marie and lighthouses. We haven't been that route except for short periods but it's a good road. We usually travel I-70 through Kansas City (long boring drive) St Louis, then you could drop down to I-64 into Louisville, Lexington KY for more scenic routes. West Virginia is beautiful! From Charleston WV, I would drop down to get in I-81. Beautiful drive. Stay on interstate highways tho. We liked stops in Kansas City, St Louis, Indianapolis (to see the speedway).
