Boston to Philadelphia route

Take the train.. :) No, just kidding. If you are not familiar with them, almost ANY of the paved roads within about 50 miles of NYC can be maddening. As FordTruckGuy has suggested, you want to give NYC a wide berth to the left as you go south. I-287 basically loops around to the west, and if you felt really adventurous, you could get on I-80 Westbound and then take the North East extension of the Pennsy Turnpike SOUTH to the western suburbs of Philly. Failing that, stay on 287 until it hits I-95/The Jersey Turnpike around Metuchen and then head south. But before you do this, just for kicks, zoom in on the intersection of I-287 and I-95 on Mapquest or something. If that plate of asphalt spaghetti doesn't make you dizzy, then you'll be fine. Or, you could continue east PAST I-95 a few miles, grab the Garden State Parkway, and take it south to I-195, which you can then take due east to Trenton. It depends a lot on where in Philly you want to go - there's a vast difference in the roads and getting around between Northeast Philly, and South Philly. If you're looking to do the 'touristy' things around center city like the Lib Bell, Indep. Hall, etc one word of advice - DO NOT take a trailer or RV into town. Like most pre-Revolutionary east coast cities, many streets are about 7 feet wide and people park all the way to the corner, making right turns an adventure in community relations. If an RV is your only means of transport, stay in Jersey, look for the PATCO high speed line stations that run from about 20 miles EAST of town right in to center city, and park at the train stations. PATCO is cheap, fast, and reasonably safe.