It would depend on where exactly you want to end up... Farther East.... Or Farther West....
If wanting to end up west of Lancaster PA then take 84 to 81 . . If staying along the coast , I would do the tappenzee bridge ..
I have traveled round trip to Marlborough MA and North of Philly 4 times in the past 2 weeks, The LONGEST it took me not towing was 5 hours 1 way (accident ) .. IF you time yourself around 95, there is no route faster , smoother YES , faster , no..