395 is an incredible road, the scenery is breathtaking, especially now with the Sierras capped in snow! 395 itself is big rig friendly, 2 lanes in both directions much of the way, no nasty curves, and grades similar to what you would find on an interstate.
However, are you looking for the quickest most direct route or are you planning to take a couple days? Working your way over to 395 from LV will take time as well as going over the Sierras to Sacramento
How do you plan to get from LV to 395? 190 through Death Valley is scenic but has steep grades, curves and while doable will take some time.
How do you plan to get from the eastern Sierra to Sacramento? The high Sierra passes (120,108,4) are closed with snow, you will have to go farther north.
With a little more information we might be able to give you some better recommendations :)