Well, the most direct route would be 285 north to I40 west to I25 north. If you have time to make a couple of stops along the way at some scenic sites you could take 285 north to Roswell, then take 380 from there to see some Billy the Kid country and continue on to I25 north. You could also jump off 380 and take 70 into Ruidoso for some high elevation fun, you could stay on 70 and head over to 54 south to Alamogordo if you would like to catch White Sands. Anyway, whichever route you choose to go have a great time in the Land of Enchantment.