Going to Central American can be easy or tough. Some areas are very tough and you must be watchful of surroundings. There is much to see. I would make sure you have some sort of communications device and let people know where you are. GPS that has maps for area would be beneficial.
Had issues aroung Chulateca, not much from locals but transientes.
Having been on many of the roads, my biggest concern of an RV is the tires and suspension. Better tire with stronger sidewalls will be of help as there is many potholes in the paved area, especially in the Guatamala, Honduras and San Salvador area.
You may want to invest in upgraded shocks forsame reason.