Colorado hwy 24 from Leadville to I-70

Weather should be good. It's not much of a climb from Leadville to Tennessee Pass. It's a long drop to I-70 with a few switchbacks just past the summit and a couple more just before Minturn. Pretty drive. Probably the biggest hassle right now is I-70 through Glenwood Canyon, where repairs are ongoing after a rock fall a few weeks ago. Down to one lane each direction. Just came through there this evening and there wasn't much slowing. It was after 4:00 p.m., so they may have quit for the day. I don't know how much work is done on weekends. No issues for your rig through there, just potential slowing.

As noted, another option is US 50, where Monarch Pass is your only big climb.