I believe you could travel through the Southern Tier of NYS (I-86 or NY17). This will bring you through Corning then wander a little north to Cooperstown. Depending on your timing after Cooperstown you can wander down I-88 to I81 and go east on on I-84 to get to HYDE Park. I would get E-Z pass. Lately they have only one cashier with the rest being E-Z pass, like MA. NY is going to E-Z Pass. I-86, I-88, and I-81 are all 4 lane interstates that are toll free. The further east you go the highways will be less and less toll free.