It's been a few years since I brought an RV through #2, but it doesn't appear to be a problem. Coming up 85 / 85D it's an easy right turn into the road that leads to where the stickers are turned in. The building is a little west of #2, so when you're through turning in the sticker you backtrack 1/4 mile, then it's a pretty hard right. Don't get in the far right lane, get in the lane just next to the far right. Occasionally the booth ahead accepts stickers, but it's rarely been open recently. You'll keep to the right, cross the bridge and there are a lot of lanes to choose from - they are tight but doable.
After customs, you are at the start of I-35, just go straight.
Last year when we crossed at #2 on a motorcycle we were treated with good humor and no search. They just looked at the passports.