Several routes will get you there. Avoid Atlanta! This is our regular route out of N Georgia to Florida.
Head out of Helen towards Cleveland. Turn left at the Sautee Valley. You will see the indian mound and the cupola on top in pasture. The turn will take you toward Clarkesville. Stay on Ga 17 through Clarkesville. Watch the signs, there is a couple of turns in town. This will take you to US441/23. This will take you to the Athens. Watch the signs again and take the Ga 10 loop / US441 bypass around Athens. Follow 441 to Madison and Eatonton. Stay off I-85 south toward Atlanta. Huge construction going on with terrible traffic jams.
Eatonton to Macon and in Macon west on I-16 for a couple of miles to I-75 South.
In Wildwood you can get the Florida Turnpike (toll road) or go state roads (Fla 50) to Orlando. We don't use I-4 this time of year. Traffic is as bad as Atlanta.