We try to get up that way every couple of years ..have done 13 round trips so far by RV. Our most common route is up the Florida Turnpike to Hwy 44 over to Crysral River, then up Hwy 19 to Tallahassee. From there we check the long term forecast for weather in the Midwest . If any storms are forecast, we will head west on I 10 to the town of Breaux Bridge, then I 46 (or is it I 49)?,up toward Dallas/Ft Worth. Then cut up to Amarillo Texas, across west to I 25 to Colorado Springs and sometimes on north to the Canadian border. Other times we will head west from the Springs to Montrose Colorado, north to grand Junction, west on I 70 to Green River Utah, north to Salt Lake and on to the border.
One trip we went north to Boston first, crossed into Canada and headed west through the Prairie Provinces. Gives one a real taste for how large Canada is east to west.
Other times if the weather looks good, we will from Tallahassee, go north to Montgomery, to Birmingham Memphis, west to Tusla Oklahoma, cutting north to Salida Kansas, the west to Denver and on north on I25. One trip we went north up to Davenport Iowa, up to Hwy 2 west to Montana.
The last 4 trips we have taken our truck camper, so more comfortable going through some of the larger towns on our route. We may take our 5th wheel if we go back this summer. The extra room would sure be nice to have at times. But the same truck gets about 2 mpg better on fuel with the TC on rather than the trailer. So we will see.
A travel trailer is about the only RV we haven't used in the past, just never owned one. Most trips were in a mid sized Class C, not towing. Six of them I believe. The Fifth wheel worked fine the year we took it. I have never found the vehicle that we are using has been much of a factor in the enjoyment of the trip. Loved every trip. Some of them solo and most with my wife.