Oh my, isn't it all personal preference.
We lived in OR for over 15 years and (IMO) Yamhill Co for pinot noir, Yakima valley (WA) for the sauvignon blanc (if either of you is sensitive to wine-sulfides-tanins induced vasomotor headaches then Pac NW blancs may be the answer (spouse can't drink anything but Pac NW blancs and some South American whites for fear of headaches).
If you've never toured the area, I wouldn't pass up the Hood River Valley, Yamhill Co for the pinots and if driving through the gorge to the west coast I'd consider stopping @ (from east to west) @ Maryhill (art museum and wine on the Washington side), Hood River Valley-Timberline Lodge (on the OR side) and Skamania Lodge in Stevenson, WA (over the Bridge of the Gods). Have fun.