Yes. From DC, you want to pick up I81 north. I don't know where you're planning to stay in DC, but 270-70-81 would work.
I81 goes to Harrisburg, and then onto Scranton. You have several choices to bypass NYC metro area. My choice would be I81-I78-I287-I87-I84-I90-I495-I95 into Maine. Alternately, you could stay on I81 to Scranton and pick up I84 there, however, I81 north of Harrisburg is rough and under construction and I84 east of Scranton is frequently down to one lane.
DO NOT DRIVE THROUGH BOSTON. In addition to being some of the worse traffic in the northeast, the tunnel under the city is a no hazardous cargo tunnel (no propane).