There is a big difference between both roads. If you take the turn off just past the airport turn off you are taking the Periferico Sur. The Guadalajara Macro Libramiento is far south of that it will be the southeren by pass of Guadalajara. If you are coming from Chapala on the highway to Guadalajara just before reaching the La Barca turn off there is an overpass crossing the highway you would then turn right exiting and you will be on the Guadalajara Macro Libramiento which is different then the Periferico Sur and takes you right onto 80 D . You don't even see the city Guadalajra from this road. The part from there going west will be on the south side of Laguna Cajititlan and will eventually join up with Mex 15 D west of Guadalajara.