Harrisburg Pa to Kissimmee, Fl Best Route/Issues

I have done the trip, starting from about 100 miles NE of Harrisburg, every year for the last 15, or so. I tried all different routes, and finally settled on the one listed by rrupert. The key to keeping the journey as pleasant as possible is to spent the least amount of time on 95 as you possibly can. The rt 77 stretch from 81 to the NC line can be a real trouble spot if the weather is bad, but other than that it's generally quiet and low keyed compared to the insanity on 95. Good luck.