Below are some alternate routes that are suitable for different size rigs.
With all the changing conditions and rain still in the forecast, check individual routes before taking one.
Recommend alternate for large rigs is I26 to I81 then back south to I40.
Medium size rigs can take 25 through Hot Springs over to Newport.
Smaller rigs can take twisty 209 to Hot Springs to 25 to Newport.
All rigs can go through Cherokee up and over the mountain on 441. Be warned this is a steep winding road up then back down, but does provide some nice views though is the slower of them all.
The truely adventurous, under 5 ton vehicles can take the road towards Cataloochee but when the road turns to pavement to the left, go straight on the gravel road. Just stay on it and it will eventually come out to I40 at Waterville exit on I40. This is 16 miles of single lane gravel roads and will take almost an hour so not the fastest by any means.