I-79 in West Virginia

Can't speak to the part south of Morgantown, but from there east I think you'll be fine. We did it going west back in 2012, from here in S Jersey. I don't recall any tough grades westward, but they might look different going east.

I-68 to Hancock is a very nice ride, no probs. And then I-70E to, I would assume, I-81 is also easy. If my old Bounder can do it, anything can.

My blog post of that day:
http://lens-flair.net/blog/day-1-salem-to-springfield-ohio/