I40W in NC~ I75N in TN Mountains terrain? expectations?

Some good input from posts above. Not knowing where you're starting or where you're ending, the general information is solid, places to watch out for.

Presumably, at some point, you may have driven the mountains/hills areas of your region, the Berkshires, the Greens and the Whites, perhaps the Catskills or Adirondacks. Won't be a whole lot different in places, and will also be just as scenic in places. Taking your time and enjoying the drive will make it less stressful.