Spindrift, I drive the Columbus to Indy on I70 almost weekly. Home is halfway between the two. While 70 is rough, I would not avoid it. There is some construction between Columbus, Springfield and Dayton and again at Brookville but it only takes 3 lanes down to 2 and does not create back ups. If you are traveling through the area on the weekend they are doing construction nights and weekend from the Ohio line mile mark 156 to Centerville Indiana mile mark 145 which can back up. If you hit the state line and it is backed up you can take the first Indiana exit 156 (40 west)and follow US 40 to route 1 and go north back to I70. There is some construction near Mt Comfort Rd just outside Indy and it generally does not create back ups.
Indy is always slow at rush hour but the fastest route on 70 is always straight through town on 70. 465 North will always back up worse than 465 South if you decide to not go straight through Indy. west of Indy I don't travel often and cannot help you.