We generally take the most expedient route to reach our destination(s). And that typically involves both. But interstates by nature of the limited access points, no direct traffic crossovers, generally wide medians, and often retaining walls or cable systems separating the opposing traffic are much safer. Same for other similar major highways that may not have interstate designation. Narrow undivided two lane highways, while much more scenic, will be worse.
Certainly pros and cons of each. Personal choice.
