Mass Pike Boston to Venice FL

Best route no question is 81,77, 26, 95.....I have used them all. 66 isn't bad but brings you north of Richmond

BUKHRN I was thinking 84 and going around Hartford on Charter Oak Br to 91 to 684 to 84 to I think it is 287 to 78 and out to 81. I was definitely thinking we took 66 across to 95 but people are talking about 77 but looks further. NOT SURE of course given I do not have knowledge of doing it that way and it may be a better way.

Anyone go 81 to 66 to 234 to 95 down to FL and then a route down to Venice? 77 is pretty far down 81 before crossing over to 95 and it looks like more miles than 66?

If the weather is threatening I get off I/84 at the first PA exit and take US 209 to I/80 to PA 33 to I/78 then to I/81 south (it's mostly flat). This eliminates PA mountains with fog and snow. Nice weather I/84 to I/81.

My standard route (from Boston area) would be I-90 to I-84 to I-81 to I-77 to I-26 to I-95, and then in Florida A1A to US-301 to I-75 at Ocala.

For variety, I sometimes go I-81 all the way to I-40 to I-75, but this means going through or around Atlanta, which is sometimes not too bad...and sometimes a character building experience.

Another not unreasonable option, though somewhat slower going, is to make your way to the Garden State Parkway and then take the Cape May ferry and Chesapeake Bay bridge/tunnel and head on down e.g. US17 until it intersects I-95. That gives the opportunity to stop at a variety of interesting coastal places, such as Assateague and Cape Hatteras, and avoids the worst of city driving.

^^^ What they said... kind of

Take 84W to 81S to 77 South.. around Charlotte grab 85 South

When close to Atlanta, get on 75 South right to Sarasota/Venice

Not sure where or why you'd hit 78 off 84, i'd take 84 to Scranton and hit 81 then down to 77 and 26, you'd stay completely away from all the nightmares of NYC, Balto-Washington and Richmond.
Longer, but far more scenic and relaxing.