Miami to Naples on Route 41

It is big rig friendly, we take it all the time

We also take it all the time. I would be careful if taking it at night. You never know what might be in the road.

Usually lots of alligators in the ditches

Wife counted over 100 on that rt.

It's a US highway with plenty of big trucks using it that are taller than you and before you get to Naples you will be hoping to see some trees... it's through the Everglades.
Go to Google maps and turn on Sat view... you'll see what I mean.

Roadpilot wrote:
We also take it all the time. I would be careful if taking it at night. You never know what might be in the road.

If you a referring to alligators, keep an eye out day and night.

Their mating season begins in April and they move around a lot. The bulls are NOT in a good mood.

The trip across US 41 is much more scenic IMHO.

That used to be the primary route before Alligator Alley (I75) opened. Scenery is pretty similar on both routes but easier to look at on a much more narrow road and at slower speeds. Once 41 turns northward past Golden Gate its a traffic nightmare all the way to Tampa.

Stop at Shark Valley (Everglades NP) if you have some time and take the tram ride. And watch your speed thru the Seminole Reservation they do have speed traps.

Personally, I think the scenery on I-75 through the everglades is pretty good, although there's not much to see. But less traffic on I-75, but, you do have the toll.

Taken 41 many times. Perfectly able to handle big rigs.