One thing for sure. That big El NiƱo is going to make it an interesting Winter. It generally means a warmer than normal Winter for the Midwest and Northeast. Not that it can't be ice and snow too.
One map I saw earlier today predicted a cool and wet band all the way from Southern California across thru Texas and over all of Florida.
Personally, I'd head straight for Jacksonville and turn right. But if you started out on a northern route and watched the weather moving in very carefully you could eat up some miles that way before perhaps being forced south along the way.
On a northern route, of course, you would be traveling winterized and have few if any open Campgrounds.
Let us know how it goes. Would love to hear from you along the way.