Planning a trip from Long Island, NY to New Orleans in late October, Begining of November. Looks like Interstate 81 is the best way, but heard it is very Mountainous and could get snow that time of ye...
If you have a day or so of slop in your schedule, you could also just stop and wait out any storm that is likely to occur around that time of year. Generally getting the Interstates cleared is the top, or nearly the top, priority of road crews for winter storms.