We used to travel this time of year regularly. I have some interesting advice based on real world experience.
Others have said watch the weather. This is very true, but start watching the national weather about a week before your planned departure. It may force a change in plans.
Be ready to hold up. What kills truckers, pilots and boaters?? Trying to push the weather. Mother nature has been doing this a long time and is very good at making storms.
To this end, depart with fuel and provisions onboard for three days. It is very easy to get held up for a solid day. It is not that hard to have to wait longer for the idiots to have the accident that they deserve and go home. The third day is so you don't have to worry about a second hold up.
It is kind of fun sitting in the warm coach in an highway rest area or a truck stop (don't count on any cramp grounds to be open) and watch the wreckers haul those "Gotta Git Theres" out of the ditches.
You have a self contained coach, take advantage of that.
Matt