Either way is about the same miles and there is some construction on both I-75 and I-95. If you choose I-75 make sure you don't hit Atlanta during rush hour. Go through on a Sunday morning is your best bet. Stay in the middle lanes as some right hand lanes are exit only. How many miles per day do you want to drive? For the first stop (5-6 hours) we usually stay at Holiday Tra-v-L Park in Chattanooga. 2nd stop: Twin Oaks RV Park, Elko GA. (3.5-4hrs) 3rd stop: Quail Run RV Resort Wesley Chapel FL - (4.5-5 hrs). For the last stop you can find a spot in Naples FL or if you want a true Florida experience, look up Ortona Lock & Dam Campground on FL Hwy 80 near LaBelle FL. www.recreation.gov search for Moore Haven FL. Nice campground water & electric no sewer. See if you can reserve site 40. Pull thru on the canal. If you have pets do not let them off lease! Alligators in the canal. You can then take FL Hwy 80 east to Clewiston and take US27 south. Hwy 80 is a 2 lane hwy but a good one. that last stop is about 3.5 hours from the last stop and about 5 hours to Key West. Maybe someone else can give suggestions for I-95 so you can compare. Have a great trip!!