A lot depends on where in Ohio you begin your journey. If you live in the western part of the state and are going to central or western Florida I75 may be best. If, however, you live east (we are one mile from I77)you do have options. We use I77 to South Carolina and then cut over to I95 and depending on where we are headed from the Jacksonville area, stay on I95 or angle across to I75. That's just our preference.