You're going to get answers all over the board on how long to drive in one day. Back when I was 19 and in the Air Force I drove from Wichita Falls, Texas, to Sacramento, California in one straight shot in less than 30 hours. You won't see me do that now. A few years back we went from Central California to Oshkosh Wisconsin in the Class A with a toad. I left the first night after work on Thursday. We did about 250 miles that day and stopped just the other side of Reno. On Friday and Saturday I did over 700 miles each day. On Sunday we did the last 400 or so miles and got into Oshkosh in early evening. That was about 2200 miles in basically a three day weekend. Your trip from Orlando to Vegas is only 200 miles further. So you can do it in three days at the rate I did it. But you'll have people on here tell you they drive 200 miles a day max. It all depends on what you can handle.