I did this some years ago, though in a SUV.
I'd driven to Telluride from Moab, and intended to do some easy back roads. But a storm just passed through, so I choose to stick with the main highways. Drove to Ouray, and the over 550 to Silverton and Durango, and then to Cortez.
From Cortez I took county road G (turn off near the airport), which heads due west across the south side of the Ancients monument. We took one modest hike to some ruins. We hit 162 at Aneth.
145 Lizzard Pass is supposed to be an easy alternative to 550, though I didn't drive it.
G was a typical paved county road, no significant grades or curves, but not fast. Once you get into Utah there are lots of side roads, mostly gravel/dirt. On an even earlier trip we spent a day/night at Hovenweep, just a bit to north of this route.