Based on the least traffic going and coming...Best day would be Sunday or 2nd best Saturday. You need to head back to Pt Mugu before 1PM on Sunday to beat traffic. Saturday head back by 2PM
During the week Tues, Wed or Thurs. leave before 6AM or after 10AM return from San Pedro by 2PM at the latest.
HWY 101 to I-405 to HWY 110 which ends at Gaffey street. Gaffey will get you into the heart of San Pedro. If you want to go to the harbor use Vincent Thomas Bridge/ Harbor Blvd. offramp and take Harbor Blvd to head to the harbor (Battleship Iowa signs)