Recommendations for a a route from PA to CO avoiding IL

If you cross at Cairo you will be in IL for 1 mile as you go from the Ohio River Bridge to the Mississippi River Bridge. You can take 60 (divided hwy)across to near the Mo state line and either wander back up to I70 or do what I do and take 400/50 all the way to Pueblo which is often the route I take from Southern MO. The next crossing of the Mississippi south is the Dorena Hickman Ferry. The next south is at Dyersburg. http://dorena-hickmanferryboat.com/tolls.htm