I've pulled my fifth wheel on 385 to Big Bend many times. The road is good. Fuel up in Ft Stockton and Marathon. Diesel and gasoline are available near Panther Junction in BB, and gasoline at the Basin. There are only two places in BB that will accommodate your trailer: the NP campground at Rio Grande Village (no hookups of any sort, water is available, there is a dump) and at the concessionaire "campground" at Rio Grande Village - full hookups; the concessionaire campground is a large parking lot, but not too awful. It will be HOT at Rio Grande Village, not so bad in the Basin - which has no places that can accommodate your trailer. Vehicle break ins are fairly common in lightly visited areas, read the BB daily report and warnings. In the campgrounds and higher use areas your vehicle will probably be OK. Your main safety concern will be keeping hydrated.