Most of the interstates have "challenging" sections when they cross the high ground. I-70, 80, 90 all have at least one or more "passes" that will slow you down. I've also been caught on I-90 behind slower moving vehicles to the point that the airflow through the rad was cut, and the temp gauge let us know pretty quickly. I think the more southerly interstate crossings might have slightly better grades for climb/descent. I would make sure the engine cooling system is in good shape, and change the rad fluid and the engine oil before you hit the hills, and you'll probably be fine.