69 from Indy to Ft Wayne is a good route BUT WAY OUT OF THE WAY!
When my in laws were in St Louis our preferred route was 55 because it traveled faster than 57. If we were stopping to see family on the way we would travel 31 south to 70 west. (though Indy)
for us the Indy route took longer both directions but had free meal in the middle of the trip. The Illinois routes traveled faster on bigger roads. But the tolls on 80/90 are terribly expensive for more that 3 axles now.
I guess for me today I would use the Indy route (In laws are there now and the construction at 465 and 31 is a non issue as it travels just fine now) because of the tolls.