We've drivin that route, or portions of that route at one time or another.
My daughter and family lived near Ames, Iowa for a few years, so we became very familiar with the I-80 section. And then she moved to Kansas City, MO, so we became very familiar with the I-70 route (from Indiana).
I can't attest to anything West of Kansas City, although we have driven I-70 further West, but that's been many years ago.
So, what we found we liked best leaving Kansas City, was to take I-35 and then hit US 36 to Hannibal, Mo. (Be warned, this is 4 lanes, but no traffic, and very few gas stations along that route, so make sure you are filled up after you get past Kansas City, before exiting I-35.
From Hannibal, Mo, stay on I-75 till you hit I-55 at Springfield. Turn North on I-55 at Springfield until you hit I-39 at Bloomington, Illinois. Stay on I-39 until you hit US64 and go to Chicago.
We've driven these roads before over the years at one time or another, and I find them much more friendly than following I-80 from Des Moines to Davenport and 35 from Kansas City to Des Moines.
Good luck!