I am not aware of any RV that has any 240 volt equipment - but I don't know everything by a long shot. We do not need 240 volts in our RV.
So it seems you do understand that what we get in many RV parks in the US is 4 wires from a 50 amp outlet. One Ground. One Common or Neutral. And then two "hot" legs of 120VAC each with a maximum capability of 50amp - for a total of 100 potential amps. Many are wired so one of these 120 volt 50amp legs goes to one Air Conditioner plus a number of outlets and other appliances - while the other leg might go to another AC and other outlets and appliances. That's as simple as I can make it - trying not to be technical.
When we see these ISB voltage regulators in businesses in Mexico there are always two of them as these are commercial buildings wired for two incoming legs just as our RVs are. My guess would be you wire this just as you would a breaker box going into a building that is also fed by two "hots" but only one ground and one common/neutral - standard procedure - and the way our RVs are probably wired. But in order to have the two legs providing 120 volts at 50 amps each you would certainly need to have the two voltage regulators - one for each leg - which could be expensive and unnecessary in the US.
But in Mexico we have an entirely different situation so we wire differently for our RV since we are not going to be seeing any 50amp situations. We get 15, 20, 30 amps - not 50 - not in RV parks in Mexico - Maybe rarely - I think the resort in Campeche has 50amp. So we are not concerned about having two regulators. We have one. I wired it so I can feed one leg from a Mexican pedestal into it and come out with a 50amp outlet (not providing 50amps but configured as that type outlet to plug in my 50amp plug - I will not get 50amps - lucky to get 30amps - and that would be from one source feeding the two legs - so a total of still only 30amps and not the potential 100amps we get in the US. So the whole thing is entirely different and since we are talking about Mexico here we are not concerned about using one in the US. I do have mine with us in the US and I think I have used in on bad 30amp circuits maybe twice in the past 5 years - so to me the US part of this is almost moot.