If you're first leaving in October I would suggest heading west first rather than Florida. You don't want to get stuck in bad weather. September would be even better.
From Ohio take I-80 which will put you into the Napa/Sonoma areas of 'wine country' - just north of San Francisco. Also, for both Napa/Sonoma there's Napa Valley Expo RV park which would be a very good stopping point or...pick out a RV park along Hwy 101 (NOT Hwy 1 for your first time). Make a reservation now as that's a popular time of year.
If that area and amount of time for touring is enough for you then return via I-80 to Hwy 395 at Lake Tahoe/Reno area. Take 395 south to I-40 (you'll miss a lot of Los Angeles/San Francisco traffic by the very scenic Hwy 395 (We just drove that way, once again). Then take I-40 east to connect to I-10. (Between CA 395 and Lake Havasu, AZ there are very few RV parks so when you find one closer to the 395 end you'd better take it for a night.) Lone Pine along 395 is a neat place to explore (lots of westerns made here) and has a nice RV park - Boulder Creek. You could even check out Death Valley from Lone Pine with your vehicles if you don't want to take your RVs there.
You can get off I-40 at the CA/AZ border on AZ Hwy 95 (a very good highway) and head along the Colorado River through Lake Havasu (a good stop - nice state parks) on to Parker to the 'famous' Quartzsite - which will not have thousands of RVers until January :) - and then to I-10 east to Florida by Nov/Dec.
Have a fun trip but don't rush it...lots to see along the way!