Yep! Been on it many times... Only live about 40 miles from Ten Sleep. As others stated, it's a bit steep with switchbacks near the end before dropping into Ten Sleep. Also, as stated... Believe the signs! If you start out with too much speed, you can get the brakes pretty warm getting it " whoa'd up"! A beautiful drive, but respect it!
Going the other way, into Buffalo is visually misleading. A quite long, moderately steep, few curves road. Several years ago, an older couple in a motor home, burned up the brakes, went thru the intersection into some buildings. One was killed (wife I think). Also, use caution when in hilly/mountainous areas. memtb