Yes you can use E-Z Pass with the 5th wheel but you need to get one for the tow vehicle and trailer. If you are coming from NE, PA , I would go up I-87 to the eastern Adirondacks and stay at the North Pole Resort in Wilmington, NY, tell Jim I sent you. As some one already mentioned the Iron Man is held here so bicycling is great. I would then take Rt. 30 south to Blue Mountain lake and visit the Blue Mt. Museum. Then pick up Rt. 28 west and go to or thru Old Forge and pickup Rt. 12 south to Utica, NY and pick up I-90 west to the Finger Lakes.
Enjoy the Adirondacks.