Hilton Head island, SC

We found this place by accident and loved it. Zero ambiance (It's in an office park for crying out loud!), just great food, big portions and very reasonably priced.
http://seashackhhi.com/

P.S. - DW wanted me to add that it was surpassingly friendly as well!

Thanks all. Please keep the suggestions coming!

I can personally vouch for the Crazy Crab seafood restaurant. We ate at the Jarvis Creek location, not too far from the motorcoach resort. http://www.thecrazycrab.com/

After doing much research a couple of years ago when we were at Hilton Head Island, I found this place. We visited there for lunch. It was one of the best meals I have ever had at a restaurant before. I highly recommend it!

We liked Santa Fe Café. It's a bit spendy, but the food was great when we were there.

We stayed at out door resorts beautiful campground there is a restaurant under the bridge comeing in to island I think its called sunset grill all the locals go there and a other one near that one some are pricey and there are some restaurants by the harbor if you ride bikes there are a lot of bike paths have fun.