Ok to run a generator at night if no one is around?

Are there safety issues for running a genny at night, outside of CO concerns? In another thread, a member wrote this:

2oldman wrote:
On a windless night, your area will be blanketed in CO. I've known very few boondockers to run a/c on a generator, and nobody who does this at night.

As for CO, I am planning on extending it to the max length of my cable, 75 feet away, to cut down on noise. That'd have to be a lot of CO to be a problem. It'd be chained around a tree.

As for noise, I won't be a rude neighbor. Before going camping I'll see if there will be anyone close by. The first planned location is on a friend's property, so we'll know who will be there ahead of time. Based on what he's told me about the place, I don't believe anyone will be close enough to hear it. The genny is rated at 68 dB at 20 feet, thus at 75 feet it's about 55 dB, same as normal office noise or a quiet stream. And when our windows are closed, I doubt we'll hear it at all. If his neighbors are as far away has he says noise won't be a problem.

Are there safety issues? What do boondockers do if their wife won't go if they can't run an A/C at night? Leave her at home?