Well it seems everyone has dumped you in the Catskills with no additional advise. So............. You can either follow US 13 south to US 17 and stay on the coast or you can head inland and travel the Skyline drive thru the Shenandoah National Park to the Blue Ridge Parkway and end up in the Great Smokey Mountains National Park, either way the sites are numerous. Since travel speed in not a concern, the Skyline and Blue Ridge would be great early Oct thru mid-Nov travel with the changing leaves.
Of course this is just my $.02
G George