We had motorhomes for 17 years both gas and diesel. The biggest bang for the buck was increasing the air intake from 4" to 5" and adding a performance muffler.
Getting a lot of air into and out of those engines improved our fuel economy by .25, cooled the engine on climbs, and made it a tad bit quicker on starts.
A side benefit was climbing grades....our mph increased from 45 to about 55mph.
I looked at K&N filters, but was concerned about the dirt passing. But there are high flow filters that clean as well as stock filters. The biggest gain was the muffler.
First off, it weights 1/4 of the stock muffler and it's straight through design was very apparent in performance. It increases the noise slightly, but the wife wasn't bothered by it. And that's always been my rule of thumb. :)
I put an MBRP muffler on our last ISC, but there are also Magnaflow and Aero to name others. We also used a high flow filter, but I don't remember the name. It was one of those that were on the filtration test report a few years back. Be careful with K&N and AFE.
Just my .02 worth.