Weight capacity will increase a small amount with a 4X2. Most everything else is the same when towing. Not too much of a justifier, but consider the future use of a 4X4 with a transfer case. If you change your configuration and tow your F350, 4 wheels down, you will already have the neutral to disengage your tranny from the rear wheels. In my days past of towing a TT, all the F3500 I could find on GMC lots were diesel and 4X4. Single rear wheel models were just being introduced. I also use the transfer case low range if the back roads are bumpy. Sometimes it takes 4X4 to get over wet grass. 4X4 has allowed us to traveled on vs. turning around. Maybe the market has changed, but a gas engine, 4X2, one ton was impossible to find on a dealers lot. Could have saved $8000 in 2005 if I had wanted to order and wait 9 weeks for a gas version.