It's a myth that it's easier to set up a MH assuming you have a toad. With auto leveling, it's pretty much the same level of effort.
Both drive very nicely assuming you don't try to cheap out (a MH asked to do more than it's capable of is not fun either).
Steps are a bit of an advantage for a MH but either require a few steps to get in and out.
For the same money, you will likely get more living space in a 5th wheel (remember the cockpit eats up 5-6' of the MH length). Plus you have less maintenance as there is only one drive train to maintain and any shop can handle a pickup. Many shops don't handle MH's.
In the end, either will work fine.