Never owned a motor home but it strikes me it would be more convenient for traveling. You do have an extra powertrain to maintain but you aren't stuck with using a fuel guzzling truck that you may not need otherwise, as a daily driver when not traveling. On the other hand, with a motor home you may wind up having to buy a vehicle suitable for use as a towed that you wouldn't normally want if you were just buying a car.
We wound up with a fifth wheel because we lived on an acreage at the time and needed a truck. Otherwise I don't know which we way we would have gone. The only thing we knew for sure was no matter what you get, you will end up towing something, unless you want to use your RV as a grocery getter.